Date: April 10, 2010
Venue: Yas Island
City: Abu Dhabi, UAE
Preliminary card
- Heavyweight bout: Jon Madsen vs. Mostapha Al Turk
- Madsen defeated Al Turk via unanimous decision (29–28, 29–28, 29–28).
- Lightweight bout: Paul Kelly vs. Matt Veach
- Kelly defeated Veach via submission (guillotine choke) at 3:41 of round 2.
- Welterweight bout: DaMarques Johnson vs. Brad Blackburn
- Johnson defeated Blackburn via TKO (strikes) at 2:08 of round 3.
- Welterweight bout: Nick Osipczak vs. Rick Story
- Story defeated Osipczak via split decision (29–28, 28–29, 29–28).
- Light Heavyweight bout: Alexander Gustafsson vs. Phil Davis
- Davis defeated Gustafsson via submission (anaconda choke) at 4:55 of round 1. This bout aired on the PPV broadcast following the Etim vs. dos Anjos fight.
Main card
- Middleweight bout: Kendall Grove vs. Mark Muñoz
- Muñoz defeated Grove via TKO (punches) at 2:50 of round 2.
- Lightweight bout: Terry Etim vs. Rafael dos Anjos
- dos Anjos defeated Etim via submission (armbar) at 4:30 of round 2.
- Welterweight bout: Matt Hughes vs. Renzo Gracie
- Hughes defeated Gracie via TKO (strikes) at 4:40 of round 3.
- Lightweight Championship bout: B.J. Penn (c) vs. Frankie Edgar
- Edgar defeated Penn via unanimous decision (50–45, 48–47, 49–46) to become the new UFC Lightweight Champion.
- Middleweight Championship bout: Anderson Silva (c) vs. Demian Maia
- Silva defeated Maia via unanimous decision (50–45, 50–45, 49–46) to retain the UFC Middleweight Championship. Silva also broke the record for the most consecutive title defenses with 6 and extended his own record of consecutive UFC wins to 11.
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