Date: February 26, 2012
Venue: Saitama Super Arena
City: Saitama, Japan
Preliminary card (Facebook)
- Featherweight bout: Zhang Tiequan vs. Issei Tamura
- Tamura defeated Zhang via KO (punch) at 0:32 of round 2.
Preliminary card (FX)
- Bantamweight bout: Takeya Mizugaki vs. Chris Cariaso
- Cariaso defeated Mizugaki via unanimous decision (29–28, 29–28, 29–28).
- Middleweight bout: Riki Fukuda vs. Steve Cantwell
- Fukuda defeated Cantwell via unanimous decision (29–28, 30–27, 30–27).
- Bantamweight bout: Norifumi Yamamoto vs. Vaughan Lee
- Lee defeated Yamamoto via submission (armbar) at 4:29 of round 1.
- Lightweight bout: Takanori Gomi vs. Eiji Mitsuoka
- Gomi defeated Mitsuoka via TKO (punches) at 2:21 of round 2.
Main card
- Lightweight bout: Anthony Pettis vs. Joe Lauzon
- Pettis defeated Lauzon via KO (head kick & punches) at 1:21 of round 1.
- Featherweight bout: Hatsu Hioki vs. Bart Palaszewski
- Hioki defeated Palazewski via unanimous decision (30-27, 29-28, 29–28).
- Middleweight bout: Yushin Okami vs. Tim Boetsch
- Boetsch defeated Okami via TKO (punches) at 0:54 of round 3.
- Welterweight bout: Yoshihiro Akiyama vs. Jake Shields
- Shields defeated Akiyama via unanimous decision (30–27, 30–27, 30–27).
- Heavyweight bout: Mark Hunt vs. Cheick Kongo
- Hunt defeated Kongo via TKO (punches) at 2:11 of round 1.
- Catchweight (211 lb) bout: Quinton Jackson vs. Ryan Bader
- Bader defeated Jackson via unanimous decision (30–27, 30–27, 30–27).
- Lightweight Championship bout: Frankie Edgar (c) vs. Ben Henderson
- Henderson defeated Edgar via unanimous decision (49–46, 48–47, 49–46) to become the new UFC Lightweight Champion.
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