Date: September 23, 2006
Venue: Arrowhead Pond
City: Anaheim, California, USA
Preliminary card
- Lightweight bout: Tyson Griffin vs. David Lee
- Griffin wins by submission (rear naked choke) at 1:50 of round one. The fight, although preliminary, was aired on the broadcast.
- Lightweight bout: Jorge Gurgel vs. Danny Abbadi
- Gurgel wins by split decision after three rounds. Judges scored the bout 29–28 (Abbadi), 29–28 (Gurgel) and 29–28 (Gurgel). This preliminary bout was not aired on the broadcast.
- Heavyweight bout: Mario Neto vs. Eddie Sanchez
- Sanchez wins by knockout due to a punch at :17 of round two. Sanchez accepted the fight on short notice, replacing Gabriel Gonzaga. The fight, although preliminary, was aired on the broadcast.
- Lightweight bout: Roger Huerta vs. Jason Dent
- Huerta wins by unanimous decision after three rounds. All three judges scored the bout 30–27. Dent came as a late replacement for Jason Reinhardt, who had pulled out of the card due to lingering medical concerns with his neck. This preliminary bout was not aired on the broadcast.
Main card
- Lightweight bout: Jens Pulver vs. Joe Lauzon
- Lauzon wins by knockout due to strikes at :47 of round one.
- Light Heavyweight bout: Rashad Evans vs. Jason Lambert
- Evans wins by knockout due to punches from the mounted position at 2:22 of round two.
- Lightweight bout: Melvin Guillard vs. Gabe Ruediger
- Guillard wins by TKO due to a body punch at 1:01 of round two.
- Middleweight bout: Mike Swick vs. David Loiseau
- Swick wins by unanimous decision. All three judges scored the bout 29–28.
- Welterweight Championship bout: Matt Hughes (c) vs. B.J. Penn
- Hughes wins by TKO due to strikes at 3:53 of round three. Hughes retains the UFC Welterweight Championship
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