Date: November 12, 2011
Venue: Honda Center
City: Anaheim, California
Preliminary card (Facebook and FoxSports.com)
- Light Heavyweight bout: Aaron Rosa vs. Matt Lucas
- Rosa defeated Lucas via majority decision (28–28, 30–26, 30–26). Lucas was deducted one point in the second round for repeatedly dropping his mouthpiece.
- Welterweight bout: Mike Pierce vs. Paul Bradley
- Pierce defeated Bradley via split decision (29–28, 30–27, 28–29).
- Bantamweight bout: Alex Caceres vs. Cole Escovedo
- Caceres defeated Escovedo via unanimous decision (30–27, 30–27, 30–27).
- Featherweight bout: Mackens Semerzier vs. Robert Peralta
- Peralta defeated Semerzier via TKO (punches) at 1:54 of round 3.
- Bantamweight bout: Norifumi Yamamoto vs. Darren Uyenoyama
- Uyenoyama defeated Yamamoto via unanimous decision (30–27, 30–26, 30–27).
- Welterweight bout: DaMarques Johnson vs. Clay Harvison
- Johnson defeated Harvison via TKO (punches) at 1:34 of round 1.
- Featherweight bout: Cub Swanson vs. Ricardo Lamas
- Lamas defeated Swanson via submission (arm triangle choke) at 2:16 of round 2.
- Featherweight bout: Dustin Poirier vs. Pablo Garza
- Poirier defeated Garza via submission (D’Arce choke) at 1:32 of round 2.
- Lightweight bout: Benson Henderson vs. Clay Guida
- Henderson defeated Guida via unanimous decision (29–28, 30–27, 30–27).
Main event
- Heavyweight Championship bout: Cain Velasquez (c) vs. Junior dos Santos
- Dos Santos defeated Velasquez via KO (punches) at 1:04 of round 1 to become the new UFC Heavyweight Champion.
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